Fundus of stomach

Slide 37

The following five figures demonstrate the different structures of the fundus of the stomach.

Clinical case

One of your male patients, a self-acknowledged workaholic, complains of sharp, burning, or gnawing epigastric pain. The pain occurs 90 min to 3 h after eating and frequently awakens the patient at night. It is usually relieved within a few minutes by food or antacids or after vomiting. The vomitus tastes acidic. Barium radiographic examination used to establish the diagnosis, identified one gastric and two duodenal ulcers. What happens to the epithelium at the oesophagus-stomach junction? List the different cells that are present in the gastric glands in the different areas of the stomach. How does the mucosa of the stomach differ with repect to the glands in the different parts of the stomach? Which of these cells display basophilia and why? What is characteristic of the structure and staining of a parietal cell and why? How would you distinguish the mucosa of the stomach from that of the duodenum? What is the difference between rugae and plicae circulares? Which structures project into the lumen of the duodenum and which invaginate into the mucosa? What is a Paneth cell and where would you find it? What is the difference between villi and microvilli and why do they occur? Which nerve plexi do you find in the stomach and intestines? Where would you find Brunner glands and what to they secrete?

Microscopy

A very low magnification of the stomach fundus demonstrating the rugae and layers. Fig 37-001

A low magnification of the stomach fundus showing the mucosa and submucosa. Fig 37-002

A higher magnification of the mucosa of the fundic stomach demonstrating the structures. Fig 37-003

A very high magnification of the base of a gastric gland. Fig 37-004

A high magnification of the luminal portion of the mucosa demonstrating the different structures. Fig 37-005

Memorandum
Clinical Case	Fig 37-001	Fig 37-002
Fig 37-003	Fig 37-004	Fig 37-005