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Pancreas

  

Overview

 

Clinical anatomy

Development of the pancreas

Clinical case

Clinical case 1

Workbook tasks

Slide 50: Pancreas

H/E

This specimen is a section through the pancreas.

The pancreas is a compound tubulo-alveolar gland. It also contains endocrine tissue, in the form of islands within the exocrine tissue.

Identify:

Macroscopic

  • The mass of pancreas tissue

Microscopic

  • Exocrine section

  • The round or elongated secretory units. These are groups of cells arranged around a central lumen.

  • An island among the exocrine glandular tissue

  • Acini

  • Centro-acinar cells

  • Lobules and ducts, blood vessels and connective tissue septae

  • Endocrine section.

  • Islets of Langerhans

  • Cords of island cells

  • Capillaries

 

Draw and annotate:

A line diagram of the secretory units in longitudinal, cross, as well as oblique sections. In the line drawing of the cross section also draw the cells forming the unit.

A few cells of an island. Demonstrate the cellular arrangement in the island clearly. Additionally, draw a few (generic) cells to demonstrate the shape of groups, cords and follicles.

A lobe in which a section of the exocrine acini and the endocrine areas are shown in detail.

 

Reflection:
  1. What are the characteristics of these glandular cells?
  2. Why do the secretory units have different shapes in a section?
  3. As what type of gland is the exocrine pancreas classified?
  4. What zones are found in the cells of an acinus?
  5. Of which structures of the pancreas are the centro-acinar cells part of?
  6. What types of secretory ducts are found in the pancreas?
  7. Name the cells that are present in the islet of Langerhans as well as the hormones they produce.
  8. How are the cells of the endocrine pancreas organized?
  9. What structures are found in between the endocrine cells?
  10. What types of cells form an islet?
 

Macroscopy

 

Reflection

  1. The macroscopic build of the pancreas.
  2. Vertebral heights of the different parts of the pancreas.
  3. Arterial supply and venous drainage of the pancreas.
  4. Anatomical basis of the pancreas as endocrine and exocrine organ.
  5. Name the posterior relationships of the head of the pancreas which comes into play with tumors in the head of the pancreas. What symptoms and signs does obstruction of these structures cause?
  6. Pancreas on RT and MRI scans.

Slides

2019

2018

2018

Low magnification of a part of the pancreas.
Bleeding around the tissue.
Small blood vessel adjacent to pancreatic tissue.
Pancreatic tissue.
Isolated island of endocrine tissue.
Island of endocrine tissue.
Island of endocrine tissue.
High magnification of endocrine tissue.
High magnification of endocrine tissue.
High magnification of endocrine tissue.
Section through a nerve alongside the pancreas.
Small nerve and blood vessels in the pancreas.
High magnification of endocrine tissue.
Fat cells within endocrine tissue.
High magnification of endocrine tissue.
Blood vessel and nerve.

Medium magnification


Medium magnification of an intralobular collecting duct

High magnification

High magnification of the pancreas
High magnification of the pancreas
High magnification of the pancreas

Other

Distribution of A cells in the pancreas
Glucagon and insulin in the islet of Langerhans
Distribution of PP cells in the pancreas
Glucagon and insulin in the islet of Langerhans
Cellular composition of the islet of Langerhans

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