The patient also complains of fatigue, weakness and exhaustion, a loss of appetite and weight loss. The patient appears slightly jaundiced. The doctor suspects cirrhosis, which is is confimed with a blood test and a needle biopsy.

• Where is connective tissue normally found in the liver?
• What is a liverplate?
• What is the contents of the Space of Disse?
• Name the structures that form a classical liver lobule.
• How many kinds of liver lobules are described in the textbooks and how do they differ from a classical liver lobule?
• Describe the flow of blood through a liver lobule.
• Describe the flow of bile through a liver lobule.