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Sickle-cell anemia is an autosomal recessive genetic blood disorder, caused by a mutation in the haemoglobin gene. Red blood cells assume a rigid, sickle shape. This abnormality decreases flexibility and lead to various complications. The misshapen blood cells can slow blood flow and block small blood vessels. Severe damage to organs and tissues can lead to death and lowered life expectancy.
| Normal red blood cells |
Sickle cells |
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Source: NIH Clinical Center
Date: November 1999
Author: Drs. Noguchi, Rodgers, and Schechter of NIDDK
Licence: Public domain
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