Clinical case: sickle-cell anaemia

Sickle-cell anemia is an autosomal recessive genetic blood disorder, caused by a mutation in the haemoglobin gene. Red blood cells assume a rigid, sickle shape. This abnormality decreases flexibility and lead to various complications. The misshapen blood cells can slow blood flow and block small blood vessels. Severe damage to organs and tissues can lead to death and lowered life expectancy.

Normal red blood cells Sickle cells
Normal red blood cells
Source: NIH Clinical Center
Date: November 1999
Author: Drs. Noguchi, Rodgers, and Schechter of NIDDK
Licence: Public domain

Malaria distribution Sickle cell distribution
Malaria distribution
Source: Sickle cell distribution & Malaria distribution
Date: 10 May 2007
Author: Muntuwandi
Licence: Creative Commons Attribution-Share Alike 3.0 Unported


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