Across
- Engulf. (12)
- Appear brick-red after staining with eosin. (10)
- Final coagulation pathway activated either by the intrinsic or the extrinsic pathway, and ending in the formation of a blood clot. (14)
- Blood test for identification of blood type using antibodies and small samples of blood. (14)
- Stop bleeding by clumping and clotting blood vessel injuries. (12)
- Bone marrow- or bursa-derived cells. monocyte the large kidney shaped or notched nucleus (12)
- Earliest stage of normoblast. (15)
- Formation of blood cellular components. (13)
- Stem cells that give rise to all the other blood cells. (38)
- Secrete large volumes of antibodies. (11)
- Antigen-specific proteins produced by specialized b lymphocytes that protect the body by binding to foreign objects such as bacteria and viruses. (15)
- Thrombus that has broken free from the blood vessel wall and entered the circulation. (7)
- Cellular components of blood; that is, erythrocytes, leukocytes, and platelets. (15)
- Individual with type o− blood. (15)
- Protein-containing storage form of iron found in the bone marrow, liver, and spleen. (8)
- Inherited blood disorder in which hemoglobin molecules are malformed, leading to the breakdown of rbcs that take on a characteristic sickle shape. (19)
- Volume percentage of erythrocytes in a sample of centrifuged blood. (10)
- Leukocytes with few granules in their cytoplasm; specifically, monocytes, lymphocytes, and nk cells. common lymphoid progenitor lineage to primarily T-cells and B-cells (20)
- Accumulation and adhesion of platelets at the site of blood vessel injury. (13)
- Type of pluripotent stem cell that gives rise to the formed elements of blood. (21)
- A part of an immune response produced by basophils, and mast cells in connective tissues. (9)
- Plasma protein produced in the liver and involved in blood clotting. (10)
- Genetic disorder characterized by inadequate synthesis of clotting factors. (10)
- Give rise to both the myeloid and lymphoid lineages of blood cells. (13)
- Large cytoplasmic granules which obscure the cell nucleus. macrophage white blood cell that engulfs and digests cellular debris (8)
- Compound of carbon dioxide and hemoglobin, and one of the ways in which carbon dioxide is carried in the blood. (19)
- Produces fat, cartilage, and bone, with low vascularity. (18)
- Thin, pale layer of leukocytes and platelets that separates the erythrocytes from the plasma in a sample of centrifuged blood. (10)
- Signaling molecules that may function in hemopoiesis, inflammation, and specific immune responses. (12)
- Blood protein active in fibrinolysis. (7)
- Blood plasma that does not contain clotting factors. (5)
- Oxygen-carrying compound in erythrocytes. (10)
- Excessive leukocyte proliferation. (12)
- Formation of a blood clot; part of the process of hemostasis. (11)
- Cell fragments broken off from megakaryocytes. (9)
- Form of cancer in which masses of malignant t and/or b lymphocytes collect in lymph nodes, the spleen, the liver, and other tissues. (8)
- Diagnostic test of a sample of red bone marrow. (18)
- Provide rapid responses to viral-infected cells. (19)
- Granulocytes that stain with eosin; they release antihistamines and are especially active against parasitic worms. (11)
- Multilobulated nucleus. (10)
- Heme-containing globular protein that is a constituent of hemoglobin. (6)
- Antimicrobial proteins released from neutrophils and macrophages that create openings in the plasma membranes to kill cells. (9)
- Leukocyte. (16)
- Granulocytes that stain with a basic (alkaline) stain and store histamine and heparin. large granular lymphocyte cytotoxic lymphocyte (9)
- Process which produces red blood cells. (14)
- Group of 12 identified substances active in coagulation. (16)
- Cancer involving leukocytes. (8)
- Process by which leukocytes squeeze through adjacent cells in a blood vessel wall to enter tissues. (10)
- Expulsion of the nucleus. (17)
- Circulating in the blood stream with a large kidney shaped nucleus. (8)
- Below-normal level of oxygen saturation of blood (typically <95 percent). (9)
- Antigen-specific proteins produced by specialized b lymphocytes that protect the body by binding to foreign objects such as bacteria and viruses. myeloblast differentiate into granulocytes (10)
- Liquid connective tissue composed of formed elements. plasma cell secrete large volumes of antibodies (5)
- Short-acting anticoagulant stored in mast cells and released when tissues are injured, opposes prothrombin. (7)
- Aggregation of fibrin, platelets, and erythrocytes in an intact artery or vein. (8)
- Anticoagulant that inactivates factor x and opposes the conversion of prothrombin (factor ii) into thrombin in the common pathway. neutrophil multilobulated nucleus (12)
- Excessive clot formation. (10)
- A cell undergoing granulopoiesis, derived from a myelocyte, and leading to a band cell. (13)
- Agranular leukocytes of the lymphoid stem cell line, many of which function in specific immunity. (11)
- Individual with type ab+ blood. (19)
- Green bile pigment produced when the non-iron portion of heme is degraded into a waste product; converted to bilirubin in the liver. t lymphocyte thymus cells (10)
- Cytotoxic lymphocytes capable of recognizing cells that do not express “self” proteins on their plasma membrane or that contain foreign or abnormal markers; provide generalized, nonspecific immunity. (23)
- Destruction (lysis) of erythrocytes and the release of their hemoglobin into circulation. (9)
- Last stage of development of a normoblast. (27)
- Physiological process by which bleeding ceases. (10)
- Glycoprotein that triggers the bone marrow to produce rbcs; secreted by the kidney in response to low oxygen levels. (14)
- Stem cell that derives from totipotent stem cells and is capable of differentiating into many, but not all, cell types. (21)
- In blood, the liquid extracellular matrix composed mostly of water that circulates the formed elements and dissolved materials throughout the cardiovascular system. (6)
- Glycoproteins that trigger the proliferation and differentiation of myeloblasts into granular leukocytes. (26)
- Process by which leukocytes squeeze through adjacent cells in a blood vessel wall to enter tissues. (10)
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- A stage of development of a normoblast. (31)
- Gradual degradation of a blood clot. (12)
- Granulocyte precursor. (12)
- Contains many granules rich in histamine and heparin. (9)
- Elevated level of hemoglobin, whether adaptive or pathological. (12)
- Test to determine overall general health status. (20)
- Substance such as heparin that opposes coagulation. basophil large cytoplasmic granules which obscure the cell nucleus (13)
- Protein-containing storage form of iron found in the bone marrow, liver, and spleen. (11)
- Young cell of the granulocytic series, occurring normally in bone marrow. (9)
- Lineage to primarily t-cells and b-cells. (26)
- Give rise to granulocytes, megakaryocytes and macrophages. (25)
- Relative percentage of each type of white blood cell. (29)
- Main agents of the acquired immune system. (16)
- Red, iron-containing pigment to which oxygen binds in hemoglobin. (4)
- Heterogeneous group of plasma proteins that includes transport proteins, clotting factors, immune proteins, and others. (9)
- Lymphocytes that provide cellular-level immunity by physically attacking foreign or diseased cells. (13)
- Platelet. (11)
- Type of hemopoietic stem cell that gives rise to some formed elements, including erythrocytes, megakaryocytes that produce platelets, and a myeloblast lineage that gives rise to monocytes and three forms of granular leukocytes (neutrophils, eosinophils, and basophils). (18)
- Large bone marrow cell that produces platelets. (13)
- A nucleated red blood cell. (12)
- Production of the formed elements of blood. (11)
- Cytotoxic lymphocyte. (25)
- Inherited blood disorder in which maturation of rbcs does not proceed normally, leading to abnormal formation of hemoglobin and the destruction of rbcs. (11)
- Hormone secreted by the liver and kidneys that prompts the development of megakaryocytes into thrombocytes (platelets). (14)
- Molecule of hemoglobin without an oxygen molecule bound to it. (15)
- Leukocytes with abundant granules in their cytoplasm; specifically, neutrophils, eosinophils, and basophils. (19)
- Embryonic stem cell that is capable of differentiating into any and all cells of the body; enabling the full development of an organism. (20)
- Granulocytes that stain with a neutral dye and are the most numerous of the leukocytes; especially active against bacteria. (11)
- Below-normal production of leukocytes. (10)
- Differentiate into granulocytes. (10)
- Class of proteins that act as autocrine or paracrine signaling molecules; in the cardiovascular system, they stimulate the proliferation of progenitor cells and help to stimulate both nonspecific and specific resistance to disease. (9)
- Type of b or t lymphocyte that forms after exposure to a pathogen. (11)
- Clustering of cells into masses linked by antibodies. common myeloid progenitor give rise to granulocytes, megakaryocytes and macrophages (13)
- Phagocytic cell of the myeloid lineage; matured monocyte. (10)
- Lymphocytes that defend the body against specific pathogens and thereby provide specific immunity. megakaryocyte large bone marrow cell responsible for the production of platelets (13)
- Lymphocyte activated by an antigen. (12)
- Digestive enzyme with bactericidal properties. (8)
- Normal, healthy immediate precursors of normal, healthy, mature rbcs. (10)
- A cell undergoing granulopoiesis. thrombocytes stop bleeding by clumping and clotting blood vessel injuries (9)
- Chemical signals including erythropoietin, thrombopoietin, colony-stimulating factors, and interleukins that regulate the differentiation and proliferation of particular blood progenitor cells. (26)
- Treatment in which a donor’s healthy bone marrow with its stem cells replaces diseased or damaged bone marrow of a patient. (22)
- Enzyme essential for the final steps in formation of a fibrin clot. (8)
- Arise from a monoblast, developing into a monocyte. (11)
- Disorder causing agglutination and hemolysis in an rh+ fetus or newborn of an rh− mother. (32)
- Molecule of hemoglobin to which oxygen is bound. (13)
- Hematopoiesis of granulocytes. (14)
- Most abundant plasma protein, accounting for most of the osmotic pressure of plasma. erythrocyte most common type of blood cell (7)
- Blood-type classification based on the presence or absence of the antigen rh on the erythrocyte membrane surface. (14)
- Colourless, nucleated blood cell providing defense against diseases and foreign materials. (9)
- White blood cells with granules in their cytoplasm. (29)
- Erythrocyte. (15)
- Condition in which there are too few platelets, resulting in abnormal bleeding (hemophilia). (16)
- Nucleated precursor in the erythrocytic series. natural killer cell provide rapid responses to viral-infected cells (23)
- Plasma protein that binds reversibly to iron and distributes it throughout the body. (11)
- Insoluble, filamentous protein that forms the structure of a blood clot. (6)
- Yellowish bile pigment produced when iron is removed from heme and is further broken down into waste products. small lymphocyte main agents of the acquired immune system (9)
- Primary lymphoid organ that generate lymphocytes. (15)
- Initial coagulation pathway that begins with tissue damage and results in the activation of the common pathway. (17)
- Process in which a cell is attracted to move in the direction of chemical stimuli. (19)
- Active b or t cells with basophilic cytoplasm. (16)
- Initial coagulation pathway that begins with vascular damage or contact with foreign substances, and results in the activation of the common pathway. (17)
- Hematocrit. (18)
- Condition in which there are too many platelets, resulting in abnormal clotting (thrombosis). (14)
- Immature erythrocyte that may still contain fragments of organelles. (12)
- Blood-type classification based on the presence or absence of a and b glycoproteins on the erythrocyte membrane surface. multipotential hematopoietic stem cell stem cells that give rise to all the other blood cells (15)
- Type of hemopoietic stem cells that gives rise to lymphocytes, including various t cells, b cells, and nk cells, all of which function in immunity. (19)
- A precursor cell. b lymphocyte bone marrow- or bursa-derived cells (10)
- Most common type of blood cell composed of haemoglobin and transport oxygen. (11)
- Having a lobed nucleus, as seen in some leukocytes. (17)
- Primary granules. eosinophil appear brick-red after staining with eosin, (19)
- Precursor cell for a megakaryocyte. (16)
- Deficiency of red blood cells or hemoglobin. mast cell contains many granules rich in histamine and heparin (6)
- Initial step in hemostasis, in which the smooth muscle in the walls of the ruptured or damaged blood vessel contracts. (14)
- Protein thromboplastin, which initiates the extrinsic pathway when released in response to tissue damage. (13)
- Excessive bleeding. (10)
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