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What is histology?

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Golgi

 
  • Sugars are added to macromolecules
  • Propeptides are split into active forms
  • Different molecules are sorted and packed into vesicles for transport
  • Coetzee et al p16-18
  • Wheater's Functional Histology p15-17 Make sure you understand the diagram on p16
  • Stevens & Lowe p19-20

Vesicles

 
  • Vesicles are small membrane-bound bodies and are derived from several compartments.
  • Cell surface-derived endocytotic vesicles
  • Golgi-derived transport and secretory vesicles
  • ER-derived transport vesicles
  • Lysosomes: contains hydrolytic enzymes and are intracellular digestive systems
  • Peroxisomes: role in breakdown of fatty acids and decomposition of peroxides
  • Coetzee et al p18-19
  • Stevens & Lowe p21-23
  • Wheater's Functional Histology p17-19 (3e Ed) or p19-21 (4e Ed)

Mitochondria

 
  • Most important site of ATP production
  • Coetzee et al p20-21
  • Stevens & Lowe p17-18
  • Wheater's Functional Histology p17-19 (3e Ed) or p22-24 (4e Ed)

Cytoskeleton

 
  • Microfilaments: fine strands of actin molecules
  • alfa- and ß-tubulins polymerized as filaments which are arranged as hollow tubes
  • Filamentous proteins which vary between specific cell types and are anchored to desmosomes
  • Coetzee et al p22-24
  • Stevens & Lowe p23-26
  • Wheater's Functional Histology p.20-24 (3e Ed) or p27-31 (4e Ed)

Basement membrane

 
  • Basal lamina portion consisting of lamina rara and lamina densa synthesized by epithelium
  • Specialised sheets of extracellular matrix between parenchymal cells and support tissue
  • Adhesion interface between extracellular matrix and cells
  • Regulate permeability by varying pore size
  • Regulation of cell growth and movement
  • Coetzee et al p77
  • Stevens & Lowe p55-57
  • Wheater's Functional Histology p20-24 (3e Ed) or p67-68 (4e Ed)
Quiz 3:3  
  Objective: answer 4 questions correctly.
  • Golgi apparatus
    Are small membrane-bound bodies
    Are based on lipid bilayers
    Pack molecules for transport
    Transport proteins
    Contains hydrolytic enzymes

  • Vesicles
    Break down bacteria
    Contains bacteria
    Containes peroxisomes
    Break down fatty acids
    Produce ATP

  • Mitochondria
    Produce GER
    Produce DNA
    Produce ATP
    Produce ribosomes
    Produce lipids

  • Basement membrane
    Do lipid synthesis
    Move substances
    Consists of an aqueous gel
    Regulate cell movement
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